Cholangiographic Abnormalities in Ulcerative Colitis Associated Pericholangitis Which Resemble Sclerosing Cholangitis

Overview

Journal Am J Dig Dis

Specialty Gastroenterology

Date 1978 Jul 1

PMID 685922

Citations 8

Authors

M O Blackstone

B A Nemchausky

Affiliations

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Abstract

Cholangiographic abnormalities in asymptomatic patients with pericholangitis and long-standing ulcerative colitis, which resemble sclerosing cholangitis, have not been previously reported. Endoscopic retrograde cholangiography (ERC) performed in one such patient suggesting intrahepatic sclerosing cholangitis stimulated the study of seven additional patients with largely asymptomatic pericholangitis. In seven of these eight patients, ERC demonstrated abnormalities which resembled sclerosing cholangitis. These consisted of beading and strictures mainly of the intrahepatic biliary tree (IHB). In two of the eight, the common bile duct was involved. In one, this was associated with histologic progression to cirrhosis and frank cholangitic episodes even though the initial clinical presentation and hepatic histology 2 1/2 years earlier suggested only pericholangitis. We therefore conclude that bile duct abnormalities resembling sclerosing cholangitis may be demonstrated cholangiographically in patients with ulcerative colitis who present with the typical picture of pericholangitis.

Citing Articles

Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.

Chapman R, Arborgh B, Rhodes J, Summerfield J, Dick R, Scheuer P Gut. 1980; 21(10):870-7.

PMID: 7439807 PMC: 1419383. DOI: 10.1136/gut.21.10.870.

Long-standing asymptomatic primary sclerosing cholangitis: report of three cases.

Chapman R, Burroughs A, Bass N, Sherlock S Dig Dis Sci. 1981; 26(9):778-82.

PMID: 7285744 DOI: 10.1007/BF01309608.

Primary sclerosing cholangitis: a heterogenous disease.

Thompson H, Pitt H, Tompkins R, LONGMIRE Jr W Ann Surg. 1982; 196(2):127-36.

PMID: 7092362 PMC: 1352466. DOI: 10.1097/00000658-198208000-00003.

Macroscopically-localized hepatic lesions in sclerosing cholangitis.

Touquet V J R Soc Med. 1983; 76(9):789-90.

PMID: 6620283 PMC: 1439427. DOI: 10.1177/014107688307600917.

Histological features of sclerosing cholangitis in patients with chronic ulcerative colitis.

Barbatis C, Grases P, Shepherd H, Chapman R, Trowell J, Jewell D J Clin Pathol. 1985; 38(7):778-83.

PMID: 4019801 PMC: 499303. DOI: 10.1136/jcp.38.7.778.

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