Topological Analysis of the Reovirus Type 3 Hemagglutinin

Overview

Journal Virology

Specialty Microbiology

Date 1983 May 1

PMID 6858002

Citations 12

Authors

D R Spriggs

K Kaye

B N Fields

Affiliations

Soon will be listed here.

Abstract

We previously showed that the reovirus type 3 hemagglutinin (HA) has distinct functional domains. For example, we identified one group of anti-HA monoclonal antibodies which only inhibited virus-mediated hemagglutination and another group which exclusively neutralized reovirus infectivity. Using competition radioimmunoassays, we now report that these functionally discrete domains on the reovirus type 3 HA correspond to discrete antigenic regions of the protein.

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Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases.

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