An Ehrlich Chromogen in Collagen Cross-links

Overview

Journal Biochem J

Specialty Biochemistry

Date 1983 Jan 1

PMID 6847614

Citations 5

Authors

J E Scott

R Qian

W Henkel

R W Glanville

Affiliations

Soon will be listed here.

Abstract

A well-characterized three-chain peptide [(Col1)2 X T9] from human type III collagen was a rich source of Ehrlich chromogen. The corresponding two-chain peptide [(Col1)2] was not, implying that the Ehrlich chromogen is a trifunctional cross-link. (Col1)2 X T9 also contained pyridinoline, which is not an Ehrlich chromogen. The 7S domain of type IV collagen also contained an Ehrlich chromogen.

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Separation and characterization of two polypeptide chains from the 7S cross-linking domain of basement-membrane (type IV) collagen.

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Ehrlich chromogens, probable cross-links in elastin and collagen.

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References

Brodersen R . Bilirubin diglucuronide in normal human blood serum. Scand J Clin Lab Invest. 1966; 18(4):361-79. View

Becker U, Fietzek P, Nowack H, Timpl R . Isolation and structure of the amino-terminal cross-linking region in insoluble type III collagen. Hoppe Seylers Z Physiol Chem. 1976; 357(10):1409-15. DOI: 10.1515/bchm2.1976.357.2.1409. View

Kuhn K, Wiedemann H, Timpl R, Risteli J, Dieringer H, Voss T . Macromolecular structure of basement membrane collagens. FEBS Lett. 1981; 125(1):123-8. DOI: 10.1016/0014-5793(81)81012-5. View

Henkel W, Rauterberg J, Glanville R . Isolation of crosslinked peptides from insoluble human leiomyoma. The involvement of the N-terminal, non-helical region of type III collagen in intermolecular crosslinking. Eur J Biochem. 1979; 96(2):249-56. DOI: 10.1111/j.1432-1033.1979.tb13035.x. View

Risteli J, Bachinger H, Engel J, Furthmayr H, Timpl R . 7-S collagen: characterization of an unusual basement membrane structure. Eur J Biochem. 1980; 108(1):239-50. DOI: 10.1111/j.1432-1033.1980.tb04717.x. View