Circadian As Well As Circannual Rhythms of Circulating Aldosterone Have Decreased Amplitude in Aging Women

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 1983 Feb 1

PMID 6841915

Citations 1

Authors

P Cugini

D SCAVO

M Centanni

F Halberg

E Haus

D LAKATUA

A Schramm

H J Pusch

H Franke

T Kawasaky

Affiliations

Soon will be listed here.

Abstract

Age differences in the characteristics of the circadian rhythm in circulating radioimmunoassayable aldosterone were studied on nine 20 to 26 year-old and ten 70 to 78 year-old women and ten 23 to 26 year old and ten 70 to 80 year old men in Würzburg, West Germany. These diurnally active-nocturnally resting subjects were sampled every 3 hours for 15 hours. A classical analysis of variance and a multivariate analysis of rhythm characteristics revealed major effects of age exerted on the circadian aldosterone amplitude in women (p = 0.003) but not in concomitantly sampled men. These observations complement the study of circadian and circannual rhythms in 8 young adults (15-21 years), 10 mature adults (29-36 years) and 10 post-menopausal (44-59 years) North American women, sampled at 100 minute intervals for 24 hours, once in each season, and document that the adrenocortical aldosterone-producing system remains rhythmic with at least two frequencies up to the late decades of human life, although in women it may be characterized by a reduction in the extent of spectral change after 70 years of age.

Citing Articles

Circadian clock communication during homeostasis and ageing.

Mortimer T, Smith J, Munoz-Canoves P, Benitah S Nat Rev Mol Cell Biol. 2025; .

PMID: 39753699 DOI: 10.1038/s41580-024-00802-3.

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