Immunosuppression in Kenyan Visceral Leishmaniasis

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1983 Feb 1

PMID 6839538

Citations 37

Authors

M Ho

D K Koech

D W Iha

A D Bryceson

Affiliations

Soon will be listed here.

Abstract

Cell-mediated immune responses were evaluated in 15 patients with active visceral leishmaniasis from Masinga location in eastern Kenya where the disease is endemic. Age and sex matched controls were selected from a village school in the same area. In vivo studies were carried out by skin testing with leishmanin, tuberculin, streptococcal and candida antigens. Lymphocyte blastogenic transformation to the mitogens phytohaemagglutinin (PHA) and concanavalin A (Con A) and the antigens purified protein derivative (PPD), streptokinase-streptodornase (SKSD) and leishmanial antigen (LA) was studied in vitro. The results showed that immunosuppression in visceral leishmaniasis in Kenya was both specific and non-specific. In the majority of patients there was complete anergy to all antigens in vivo and in vitro. The suppression of responses to mitogens was less marked. Recovery of non-specific responses preceded the development of specific immunity. In a small number of patients (23%) immune unresponsiveness to leishmanial antigens persisted 1 year after parasitological cure.

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References

Bryceson A . Diffuse cutaneous leishmaniasis in Ethiopia. I. The clinical and histological features of the disease. Trans R Soc Trop Med Hyg. 1969; 63(6):708-37. DOI: 10.1016/0035-9203(69)90116-3. View

Tuckman E . Treatment of Chinese kala-azar with sodium antimony gluconate. J Trop Med Hyg. 1949; 52(10):199-204. View

Veress B, Omer A, Satir A, El Hassan A . Morphology of the spleen and lymph nodes in fatal visceral leishmaniasis. Immunology. 1977; 33(5):605-10. PMC: 1445510. View

Whittle H, DOSSETOR J, Oduloju A, Bryceson A, Greenwood B . Cell-mediated immunity during natural measles infection. J Clin Invest. 1978; 62(3):678-84. PMC: 371814. DOI: 10.1172/JCI109175. View

Rezai H, Ardehali S, Amirhakimi G, Kharazmi A . Immunological features of kala-azar. Am J Trop Med Hyg. 1978; 27(6):1079-83. DOI: 10.4269/ajtmh.1978.27.1079. View

Bates S, Suen J, Tranum B . Immunological skin testing and interpretation: a plea for uniformity. Cancer. 1979; 43(6):2306-14. DOI: 10.1002/1097-0142(197906)43:6<2306::aid-cncr2820430621>3.0.co;2-k. View

Beatty D, DOWDLE E . Deficiency in kwashiorkor serum of factors required for optimal lymphocyte transformation in vitro. Clin Exp Immunol. 1979; 35(3):433-42. PMC: 1537620. View

Wyler D, Weinbaum F, Herrod H . Characterization of in vitro proliferative responses of human lymphocytes to leishmanial antigens. J Infect Dis. 1979; 140(2):215-21. DOI: 10.1093/infdis/140.2.215. View

Ghose A, Haldar J, Pal S, Mishra B, Mishra K . Phytohaemagglutinin-induced lymphocyte transformation test in Indian kala-azar. Trans R Soc Trop Med Hyg. 1979; 73(6):725-6. DOI: 10.1016/0035-9203(79)90032-4. View

10.

Aikat B, Pathania A, Sehgal S, Bhattacharya P, Dutta U, Pasricha N . Immunological response in Indian kala-azar. Indian J Med Res. 1979; 70:583-91. View

11.

Carvalho E, Teixeira R, Johnson Jr W . Cell-mediated immunity in American visceral leishmaniasis: reversible immunosuppression during acute infection. Infect Immun. 1981; 33(2):498-500. PMC: 350726. DOI: 10.1128/iai.33.2.498-500.1981. View

12.

Hepner Levy L, Mendes E . Impaired cell-mediated immunity in patients with kala-azar. Allergol Immunopathol (Madr). 1981; 9(2):109-12. View

13.

Musumeci S, Schiliro G, Li Volti S, Sciotto A . Lymphocyte changes in Mediterranean kala-azar. Trans R Soc Trop Med Hyg. 1981; 75(2):304-5. DOI: 10.1016/0035-9203(81)90342-4. View

14.

Petersen E, NEVA F, Oster C, Bogaert Diaz H . Specific inhibition of lymphocyte-proliferation responses by adherent suppressor cells in diffuse cutaneous leishmaniasis. N Engl J Med. 1982; 306(7):387-92. DOI: 10.1056/NEJM198202183060702. View

15.

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

16.

MANSON-BAHR P . East African kalazar with special reference to the pathology, prophylaxis and treatment. Trans R Soc Trop Med Hyg. 1959; 53(2):123-36. DOI: 10.1016/0035-9203(59)90060-4. View

17.

Buhler D . A simple scintillation counting technique for assaying C1402 in a Warburg flask. Anal Biochem. 1962; 4:413-7. DOI: 10.1016/0003-2697(62)90143-4. View

18.

Cahill K . LEISHMANIASIS IN THE SUDAN REPUBLIC. XXI. INFECTION IN AMERICAN PERSONNEL. Am J Trop Med Hyg. 1964; 13:794-9. DOI: 10.4269/ajtmh.1964.13.794. View

19.

Sokal J . Editorial: Measurement of delayed skin-test responses. N Engl J Med. 1975; 293(10):501-2. DOI: 10.1056/NEJM197509042931013. View