Radial Maze Performance in Three Strains of Mice: Role of the Fimbria/fornix

Overview

Journal Brain Res

Specialty Neurology

Date 1983 Mar 14

PMID 6839169

Citations 4

Authors

D K Reinstein

T DeBoissiere

N Robinson

R J Wurtman

Affiliations

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Abstract

Three strains of mice were tested on an 8-arm radial maze, an index of hippocampus-dependent spatial memory. Levels of performance differed between strains with C57Br/cj greater than Balb/cj greater than C57Bl/6j. Lesions of the fimbria/fornix disrupted performance in the C57Br and Balb strains: the C57Bl mice never performed better than chance before or after surgery. Choline acetyltransferase activity in hippocampus was not correlated with radial maze performance. These findings suggest a possible genetic contribution towards radial maze behavior.

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