Specific Reading Disability: Identification of an Inherited Form Through Linkage Analysis

Overview

Journal Science

Specialty Science

Date 1983 Mar 18

PMID 6828864

Citations 55

Authors

S D Smith

W J Kimberling

B F Pennington

H A Lubs

Affiliations

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Abstract

Linkage analysis in families with apparent autosomal dominant reading disability produced a lod score of 3.241. Since the traditionally accepted significance level for linkage is a lod score of 3.0, these results strongly suggest that a gene playing a major etiologic role in one form of reading disability is on chromosome 15.

Citing Articles

Specific Learning Disorders: Variation Analysis of 15 Candidate Genes in 9 Multiplex Families.

Cali F, Di Blasi F, Avola E, Vinci M, Musumeci A, Gloria A Medicina (Kaunas). 2023; 59(8).

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The Role of Neural and Genetic Processes in Learning to Read and Specific Reading Disabilities: Implications for Instruction.

Church J, Grigorenko E, Fletcher J Read Res Q. 2023; 58(2):203-219.

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The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.

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Patterns of biomarkers for three phenotype profiles of persisting specific learning disabilities during middle childhood and early adolescence: A preliminary study.

Abbott R, Raskind W, Matsushita M, Price N, Richards T, Berninger V Biomark Genes. 2019; 1(1).

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A molecular-genetic and imaging-genetic approach to specific comprehension difficulties in children.

Li M, Malins J, DeMille M, Lovett M, Truong D, Epstein K NPJ Sci Learn. 2019; 3:20.

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