Free-running Activity Rhythms in the Rat: Entrainment by Melatonin

Overview

Journal Science

Specialty Science

Date 1983 Mar 4

PMID 6823571

Citations 88

Authors

J Redman

S Armstrong

K T Ng

Affiliations

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Abstract

The pineal gland hormone melatonin may play a role in synchronization of rat circadian rhythms. Free-running activity rhythms of the rat were entrained by a daily melatonin injection, with entrainment occurring when the onset of activity coincided with the time of daily injections. When injections were stopped, activity rhythms became free-running again. Thus in pharmacological experiments, the time of day of melatonin administration is crucial.

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