Histocompatibility Antigens (HLA) in Multiple Sclerosis in Iran

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1978 Aug 1

PMID 681957

Citations 1

Authors

J Lotfi

B Nikbin

I Derakhshan

Z Aghai

F Ala

Affiliations

Soon will be listed here.

Abstract

Thirty-five patients (19 male and 16 female) with clinically definite multiple sclerosis and 100 healthy control subjects were studied for the A and B locus of the HLA system. A significant increase of HLA A3 and A11 of the A locus and B7 of the B locus was observed in patients with multiple sclerosis compared with controls. An increase of antigen A3 was also observed in eight cases of probable multiple sclerosis. A significant increase of both A3 and B7 was observed in patients with multiple sclerosis.

Citing Articles

Distribution of Major HLA-A, -B, -DR, and -DQ Loci Potentially Associated with Multiple Sclerosis in a Healthy Population from Southern Morocco.

Fguirouche A, Ouahmani F, Brahim I, Hazime R, Louhab N, Kissani N Clin Pract. 2025; 15(1).

PMID: 39851793 PMC: 11763420. DOI: 10.3390/clinpract15010010.

Multiple sclerosis and human leukocyte antigen genotypes: Focus on the Middle East and North Africa region.

Maghbooli Z, Sahraian M, Naser Moghadasi A Mult Scler J Exp Transl Clin. 2020; 6(1):2055217319881775.

PMID: 31976083 PMC: 6956601. DOI: 10.1177/2055217319881775.

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