The Effect of Aldose Reductase Inhibition on Motor Nerve Conduction Velocity in Diabetic Rats

Overview

Journal Diabetes

Specialty Endocrinology

Date 1982 Sep 1

PMID 6819173

Citations 30

Authors

D K Yue

M A Hanwell

P M Satchell

J R Turtle

Affiliations

Soon will be listed here.

Abstract

This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.

Citing Articles

Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications.

Oh Y Nutrients. 2016; 8(8).

PMID: 27483315 PMC: 4997385. DOI: 10.3390/nu8080472.

Ocular complications of diabetes mellitus.

Sayin N, Kara N, Pekel G World J Diabetes. 2015; 6(1):92-108.

PMID: 25685281 PMC: 4317321. DOI: 10.4239/wjd.v6.i1.92.

Molecular mechanisms of diabetic vascular complications.

Kitada M, Zhang Z, Mima A, King G J Diabetes Investig. 2014; 1(3):77-89.

PMID: 24843412 PMC: 4008020. DOI: 10.1111/j.2040-1124.2010.00018.x.

Animal models of peripheral neuropathies.

Hoke A Neurotherapeutics. 2012; 9(2):262-9.

PMID: 22415319 PMC: 3337016. DOI: 10.1007/s13311-012-0116-y.

Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a review.

McLaughlin P, Sassani J, Klocek M, Zagon I Brain Res Bull. 2009; 81(2-3):236-47.

PMID: 19683562 PMC: 2852609. DOI: 10.1016/j.brainresbull.2009.08.008.