Glucose and Insulin Changes Following a Renoportal Shunt in Streptozotocin Diabetic Rats with Pancreatic Islet Isografts Under the Kidney Capsule

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1982 Oct 1

PMID 6814976

Citations 4

Authors

H Reece-Smith

P McShane

P J Morris

Affiliations

Soon will be listed here.

Abstract

The effect on glucose metabolism of altering the site of the venous drainage of an isograft of isolated adult islets implanted beneath the renal capsule, from the systemic circulation to the portal circulation was determined in streptozotocin-induced diabetic rats. Reversal of diabetes was accomplished by the transplantation of 1000-1200 isolated islets beneath the left kidney capsule. The rate of fall of the glucose concentration (as expressed by the K value) was found to be significantly decreased in transplanted animals (1.7 +/- 0.5%/min; mean +/- SD) compared with normal animals (2.4 +/- 0.5%/min). Draining the left renal vein into the portal circulation restored the K value to that of normal animals (2.5 +/- 0.4%). However the fasting glucose concentration was significantly higher and the basal insulin levels lower in both normal and transplanted rats with a renoportal shunt.

Citing Articles

Comparison of portal and peripheral insulin delivery on carbohydrate metabolism in streptozotocin-diabetic rats.

Kruszynska Y, Home P, Alberti K Diabetologia. 1985; 28(3):167-71.

PMID: 3888759 DOI: 10.1007/BF00273866.

Prospects for pancreatic islet transplantation.

Gray D, Morris P World J Surg. 1986; 10(3):410-21.

PMID: 3088849 DOI: 10.1007/BF01655301.

High-performance liquid chromatography analysis of circulating insulins distinguishes between endogenous insulin production (a potential pitfall with streptozotocin diabetic rats) and islet xenograft function.

Chicheportiche D, Darquy S, Lepeintre J, Capron F, Halban P, Reach G Diabetologia. 1990; 33(8):457-61.

PMID: 2210117 DOI: 10.1007/BF00405105.

Insulin secretion by rat islet isografts of a defined endocrine volume after transplantation to three different sites.

van Suylichem P, Strubbe J, HOUWING H, Wolters G, Van Schilfgaarde R Diabetologia. 1992; 35(10):917-23.

PMID: 1451947 DOI: 10.1007/BF00401419.

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