Hormonal Variations During Sleep in Men with Erectile Dysfunction and Normal Controls

Overview

Journal Arch Sex Behav

Specialties Psychiatry
Social Sciences

Date 1982 Jun 1

PMID 6814402

Authors

R C SCHIAVI

C Fisher

D White

P BEERS

M Fogel

R Szechter

Affiliations

Soon will be listed here.

Abstract

Five physically healthy young males suffering from erectile impotence and five normal controls of similar age are the subjects of this preliminary report. All were studied in the sleep laboratory during 3 to 5 nights with the last two devoted to sequential hormonal sampling by means of an indwelling venous catheter. Electroencephalogram, eye movements, and penile tumescence were monitored continually through the night. Plasma LH, FSH, and testosterone were measured every 20 minutes by radioimmunoassay. There were no differences between the patients with erectile impotence and normal controls in all sleep parameters investigated, including mean tumescent time, time in simultaneous REM and tumescence, and number of full and partial tumescent episodes. Marked fluctuations in plasma LH, FSH, and testosterone were observed during sleep without differences noted between the two groups. Mean plasma LH, but not FSH or testosterone, was significantly lower in the impotent men. There were no significant differences in mean plasma gonadotrophins and testosterone between tumescent episodes and nontumescent periods in either group. A significant relation was found in normals, but not in the men with erectile dysfunction, between the occurrence of REM sleep and abrupt elevations in testosterone. Testosterone levels during REM sleep with tumescence were also consistently higher than during the condition of non-REM without tumescence in the normal, but not in the impotent, group.

References

Judd H, Parker D, Siler T, Yen S . The nocturnal rise of plasma testosterone in pubertal boys. J Clin Endocrinol Metab. 1974; 38(4):710-3. DOI: 10.1210/jcem-38-4-710. View

Judd H, Parker D, Rakoff J, Hopper B, Yen S . Elucidation of mechanism(s) of the nocturnal rise of testosterone in men. J Clin Endocrinol Metab. 1974; 38(1):134-41. DOI: 10.1210/jcem-38-1-134. View

Rubin R, Poland R, Rubin L, Gouin P . The neuroendocrinology of human sleep. Life Sci. 1974; 14(6):1041-52. DOI: 10.1016/0024-3205(74)90229-x. View

Comhaire F, Vermeulen A . Plasma testosterone in patients with varicocele and sexual inadequacy. J Clin Endocrinol Metab. 1975; 40(5):824-9. DOI: 10.1210/jcem-40-5-824. View

Nankin H, TROEN P . Overnight patterns of serum luteinizing hormone in normal men. J Clin Endocrinol Metab. 1972; 35(5):705-10. DOI: 10.1210/jcem-35-5-705. View

Hori T, Sugita Y, Koga E, Shirakawa S, Inoue K, Uchida S . Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard. Psychiatry Clin Neurosci. 2001; 55(3):305-10. DOI: 10.1046/j.1440-1819.2001.00810.x. View

Alford F, Baker H, Burger H, de Kretser D, Hudson B, Johns M . Temporal patterns of integrated plasma hormone levels during sleep and wakefulness. II. Follicle-stimulating hormone, luteinizing hormone, testosterone and estradiol. J Clin Endocrinol Metab. 1973; 37(6):848-54. DOI: 10.1210/jcem-37-6-848. View

SCHWARTZ M, Kolodny R, MASTERS W . Plasma testosterone levels of sexually functional and dysfunctional men. Arch Sex Behav. 1980; 9(5):355-66. DOI: 10.1007/BF02115938. View

Rowe P, Racey P, Lincoln G, Ellwood M, Lehane J, Shenton J . The temporal relationship between the secretion of luteinizing hormone and testosterone in man. J Endocrinol. 1975; 64(1):17-26. View

10.

Boyar R, Perlow M, Hellman L, Kapen S, Weitzman E . Twenty-four hour pattern of luteinizing hormone secretion in normal men with sleep stage recording. J Clin Endocrinol Metab. 1972; 35(1):73-81. DOI: 10.1210/jcem-35-1-73. View

11.

Evans J, Maclean A, Ismail A, Love D . Concentrations of plasma testosterone in normal men during sleep. Nature. 1971; 229(5282):261-2. DOI: 10.1038/229261a0. View

12.

Fogel M, RUBIN B, Ossowski R . Serum follicle-stimulating and luteinizing hormone and progesterone in single and multiple gestations following induction of ovulation. Am J Obstet Gynecol. 1972; 112(5):629-39. DOI: 10.1016/0002-9378(72)90787-9. View

13.

Furuyama S, Mayes D, NUGENT C . A radioimmunoassay for plasma testosterone. Steroids. 1970; 16(4):415-28. DOI: 10.1016/s0039-128x(70)80124-6. View

14.

Pirke K, Kockott G, Aldenhoff J, Besinger U, Feil W . Pituitary gonadal system function in patients with erectile impotence and premature ejaculation. Arch Sex Behav. 1979; 8(1):41-8. DOI: 10.1007/BF01541211. View

15.

SCHIAVI R, White D . Androgens and male sexual function: a review of human studies. J Sex Marital Ther. 1976; 2(3):214-28. DOI: 10.1080/00926237608405324. View

16.

Cooper A, Ismail A, Smith C, LORAINE J . Androgen function in "psychogenic" and "constitutional" types of impotence. Br Med J. 1970; 3(5713):17-20. PMC: 1700992. DOI: 10.1136/bmj.3.5713.17. View

17.

Boyar R, Rosenfeld R, Kapen S, FINKELSTEIN J, Roffwarg H, Weitzman E . Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep. J Clin Invest. 1974; 54(3):609-18. PMC: 301594. DOI: 10.1172/JCI107798. View

18.

Rubin R, Kales A, Adler R, Fagan T, ODell W . Gonadotropin secretion during sleep in normal adult men. Science. 1972; 175(4018):196-8. DOI: 10.1126/science.175.4018.196. View

19.

Fisher C, GORSS J, ZUCH J . CYCLE OF PENILE ERECTION SYNCHRONOUS WITH DREAMING (REM) SLEEP. PRELIMINARY REPORT. Arch Gen Psychiatry. 1965; 12:29-45. DOI: 10.1001/archpsyc.1965.01720310031005. View

20.

Raboch J, Mellan J, Starka L . Plasma testosterone in male patients with sexual dysfunction. Arch Sex Behav. 1975; 4(5):541-5. DOI: 10.1007/BF01542132. View