Mutagenicity Tests with Astemizole in Vitro and in Vivo

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1982 Jul 1

PMID 6812550

Citations 1

Authors

P Vanparys

L Fabry

A Leonard

R Marsboom

Affiliations

Soon will be listed here.

Abstract

Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that is can be concluded that astemizole has no potential to induce chromosomal aberrations.

Citing Articles

Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy.

Richards D, Brogden R, Heel R, Speight T, Avery G Drugs. 1984; 28(1):38-61.

PMID: 6204835 DOI: 10.2165/00003495-198428010-00003.

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