Immunoglobulin M and G Antibody Responses and Persistence of These Antibodies in Adults After Vaccination with a Combined Meningococcal Group A and Group C Polysaccharide Vaccine

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1982 Aug 1

PMID 6811434

Citations 9

Authors

E C Beuvery

A B Leussink

R W Van Delft

R H Tiesjema

J Nagel

Affiliations

Soon will be listed here.

Abstract

Adult volunteers were injected with a combined meningococcal group A and group C polysaccharide vaccine. Immunoglobulin M (IgM) and IgG antibody levels against both polysaccharides were measured in serum samples taken 14 days as well as 3 years after vaccination. For both group A and group C polysaccharides, the IgM and IgG antibody levels at 14 days postvaccination were positively related. The IgM-to-IgG antibody ratio at 14 days postvaccination was an indicator for the persistence of both IgM and IgG antibodies during the next 3 years; a high ratio meant a short persistence, whereas a low ratio was associated with a long persistence.

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