Naloxone Has No Effect on Ethanol-induced Impairment of Psychomotor Performance in Man

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1982 Jan 1

PMID 6805031

Citations 2

Authors

K D Bird

G B Chesher

J Perl

G A Starmer

Affiliations

Soon will be listed here.

Abstract

In a study designed to investigate the effect of naloxone on ethanol-induced performance deficits in man, ethanol (0.75 g/kg) and naloxone (0.4 mg) or saline were administered to 39 volunteers in a double-blind fashion. Psychomotor performance was assessed on a battery of tests (standing steadiness, pursuit rotor, simple and complex reaction times, a speeded number test and the Vienna Determination Apparatus) and blood and breath ethanol concentrations were monitored. Two experiments were performed: in Experiment 1 ethanol was given before naloxone and in Experiment 2 naloxone was administered before ethanol. There were no significant differences in either blood or breath ethanol concentrations at any time between the ethanol + naloxone and ethanol + saline groups in either Experiment 1 or 2. Although ethanol produced a significant decrement on most of the performance measures, naloxone was without effect. There was no suggestion of ethanol impairment being moderated by naloxone, whether it was given before or after ethanol.

Citing Articles

Investigating drug--ethanol interactions.

Starmer G, Bird K Br J Clin Pharmacol. 1984; 18 Suppl 1:27S-35S.

PMID: 6098293 PMC: 1463345. DOI: 10.1111/j.1365-2125.1984.tb02580.x.

Antagonism of the stimulant and depressant effects of ethanol in rats by naloxone.

Prunell M, Boada J, Feria M, Benitez M Psychopharmacology (Berl). 1987; 92(2):215-8.

PMID: 3110844 DOI: 10.1007/BF00177918.

References

Finck A, NGAI S, Berkowitz B . Antagonism of general anesthesia by naloxone in the rat. Anesthesiology. 1977; 46(4):241-5. DOI: 10.1097/00000542-197704000-00003. View

Amir S, Brown Z, Amit Z, Ornstein K . Body pinch induces long lasting cataleptic like immobility in mice: behavioral characterization and the effect of naloxone. Life Sci. 1981; 28(10):1189-94. DOI: 10.1016/0024-3205(81)90697-4. View

Hasbrouck J . The antagonism of morphine anesthesia by naloxone. Anesth Analg. 1971; 50(6):954-9. DOI: 10.1213/00000539-197150060-00011. View

Wiener P, Hogg M, Rosen M . Effects of naloxone on pethidine-induced neonatal depression. Part II--Intramuscular naloxone. Br Med J. 1977; 2(6081):229-31. PMC: 1631362. DOI: 10.1136/bmj.2.6081.229. View

Weinstein S, Pfeffer M, SCHOR J . Metabolism and pharmacokinetics of naloxone. Adv Biochem Psychopharmacol. 1973; 8(0):525-35. View

Fink M, Zaks A, Sharoff R, Mora A, Bruner A, Levit S . Naloxone in heroin dependence. Clin Pharmacol Ther. 1968; 9(5):568-77. DOI: 10.1002/cpt196895568. View

Bell E . The use of naloxone in the treatment of diazepam poisoning. J Pediatr. 1975; 87(5):803-4. DOI: 10.1016/s0022-3476(75)80315-5. View

Jasinski D, Martin W, SAPIRA J . Antagonism of the subjective, behavioral, pupillary, and respiratory depressant effects of cyclazocine by naloxone. Clin Pharmacol Ther. 1968; 9(2):215-22. DOI: 10.1002/cpt196892215. View

Blum K, FUTTERMAN S, Wallace J, Schwertner H . Naloxone-induced inhibition of ethanol dependence in mice. Nature. 1977; 265(5589):49-51. DOI: 10.1038/265049a0. View

10.

SORENSEN S, Mattisson K . Naloxone as an antagonist in severe alcohol intoxication. Lancet. 1978; 2(8091):688-9. View

11.

MacKenzie A . Naloxone in alcohol intoxication. Lancet. 1979; 1(8118):733-4. DOI: 10.1016/s0140-6736(79)91196-6. View

12.

Mattila M, Nuotto E, Seppala T . Naloxone is not an effective antagonist of ethanol. Lancet. 1981; 1(8223):775-6. DOI: 10.1016/s0140-6736(81)92643-x. View

13.

Jeffcoate W, Herbert M, Cullen M, Hastings A, Walder C . Prevention of effects of alcohol intoxication by naloxone. Lancet. 1979; 2(8153):1157-9. DOI: 10.1016/s0140-6736(79)92385-7. View

14.

Evans J, Hogg M, Lunn J, Rosen M . Degree and duration of reversal by naloxone of effects of morphine in conscious subjects. Br Med J. 1974; 2(5919):589-91. PMC: 1610781. DOI: 10.1136/bmj.2.5919.589. View

15.

Franks H, Hensley V, HENSLEY W, Starmer G, Teo R . The relationship between alcohol dosage and performance decrement in humans. J Stud Alcohol. 1976; 37(3):284-97. DOI: 10.15288/jsa.1976.37.284. View

16.

Ho A, Ho C . Toxic interactions of ethanol with other central depressants: antagonism by naloxone to narcosis and lethality. Pharmacol Biochem Behav. 1979; 11(1):111-4. DOI: 10.1016/0091-3057(79)90306-x. View

17.

Bird K . Simultaneous Contrast Testing Procedures for Multivariate Experiments. Multivariate Behav Res. 2016; 10(3):343-XXX. DOI: 10.1207/s15327906mbr1003_7. View

18.

Jeffcoate W, Hastings A, Cullen M, Herbert M . Naloxone and ethanol antagonism. Lancet. 1981; 1(8228):1052. DOI: 10.1016/s0140-6736(81)92212-1. View

19.

Belgrave B, Bird K, Chesher G, Jackson D, Lubbe K, Starmer G . The effect of (-) trans-delta9-tetrahydrocannabinol, alone and in combination with ethanol, on human performance. Psychopharmacology (Berl). 1979; 62(1):53-60. DOI: 10.1007/BF00426035. View

20.

Berkowitz B, Finck A, NGAI S . Nitrous oxide analgesia: reversal by naloxone and development of tolerance. J Pharmacol Exp Ther. 1977; 203(3):539-47. View