Lithium in Combination with Haloperidol or Thyrotropin-releasing Hormone Induces Jumping in Mice

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1982 Jan 1

PMID 6805023

Authors

I Ushijima

K Yamada

T Furukawa

Affiliations

Soon will be listed here.

Abstract

Lithium (250 mg/kg IP) administered in combination with haloperidol (2-5 mg/kg IP) or thyrotropin-releasing hormone (TRH) (10 or 20 mg/kg, IP) evoked jumping in mice. Jumping elicited by lithium (250 mg/kg) plus haloperidol (4 mg/kg) or TRH (20 mg/kg) was decreased by physostigmine (0.2 mg/kg IP) and phentolamine (10 mg/kg IP), but was increased by atropine (5 mg/kg IP) and clonidine (0.5 mg/kg IP). While the jumping was not affected by either methylatropine (5 mg/kg IP) or propranolol (10 mg/kg IP). Jumping was also induced by haloperidol (4 mg/kg IP), but not by lithium (250 mg/kg IP), administered after atropine (5 mg/kg IP) or clonidine (0.5 mg/kg IP). The results indicate that lithium plus haloperidol or TRH produces jumping in which dopaminergic and cholinergic inhibition as well as noradrenergic activation may be involved.

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