Liver and Kidney Transplantation in Children Receiving Cyclosporin A and Steroids

Overview

Journal J Pediatr

Specialty Pediatrics

Date 1982 May 1

PMID 6802949

Citations 17

Authors

T E Starzl

S Iwatsuki

J J Malatack

B J Zitelli

J C Gartner Jr

T R Hakala

J T Rosenthal

B W Shaw Jr

Affiliations

Soon will be listed here.

Abstract

The new immunosuppressive agent, cyclosporin A, was used with low doses of steroids to treat eight patients undergoing hepatic transplantation and three patients undergoing cadaveric renal transplantation. Seven of the eight liver recipients are well, including one who was given two livers. The three kidney recipients who had developed cytotoxic antibodies after previously rejecting grafts with conventional immunosuppressive therapy, have had good results despite conditions which usually preclude attempts at transplantation. The ability to control rejection effectively and safely without chronic high-dose steroid therapy may make the described therapeutic regimen valuable for pediatric recipients of whole organs.

Citing Articles

Femoral Neck Fracture in a Hemodialysis Patient after Liver Transplantation: A Case Report.

Kamada S, Kise N, Kinoshita K, Shiota E, Yamamoto T Prog Rehabil Med. 2021; 6:20210003.

PMID: 33490699 PMC: 7817843. DOI: 10.2490/prm.20210003.

Hepatic Homograft Survival in Pediatric Orthotopic Liver Transplantation with Cyclosporine and Steroids.

Zitelli B, Gartner J, Malatack J, Shaw B, Iwatsuki S, Starzl T Transplant Proc. 2010; 15(4, suppl 1):2592-2596.

PMID: 21188278 PMC: 3006672.

Pediatric Liver Transplantation Under Therapy With Cyclosporin-A and Steroids.

Malatack J, Zitelli B, Gartner Jr J, Shaw B, Iwatsuki S, Starzl T Transplant Proc. 2010; 15(1):1292-1296.

PMID: 21151785 PMC: 3000045.

Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation.

Shapiro R, Ellis D, Tan H, Moritz M, Basu A, Vats A J Pediatr. 2006; 148(6):813-8.

PMID: 16769394 PMC: 2955284. DOI: 10.1016/j.jpeds.2006.01.008.

Anti-interleukin-2 receptor antibodies for the prevention of rejection in pediatric renal transplant patients: current status.

Swiatecka-Urban A Paediatr Drugs. 2003; 5(10):699-716.

PMID: 14510627 DOI: 10.2165/00148581-200305100-00005.

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