The Sympathetic Nervous System Modulates Antibody Response to Thymus-independent Antigens

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 1981 Mar 1

PMID 6799543

Citations 7

Authors

K Miles

J Quintans

B G Arnason

Affiliations

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Abstract

Sympathetic nerve endings were destroyed with 6-hydroxydopamine (6-OHDA) and the response to thymus-dependent and -independent antigens compared in 6-OHDA-treated and control mice. A significantly enhanced plaque-forming cell response to 2 thymus-independent antigens was observed in the 6-OHDA-treated mice; in contrast the response to a thymus-dependent antigen was normal. The findings point to selective modulation of antibody response by the sympathetic nervous system.

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