Reactivation of Chicken Erythrocyte Nuclei in Heterokaryons Results in Expression of Adult Chicken Globin Genes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1981 Oct 1

PMID 6796958

Citations 5

Authors

S Linder

S H Zuckerman

N R RINGERTZ

Affiliations

Soon will be listed here.

Abstract

Activation of chicken globin gene transcription has been demonstrated in chicken erythrocyte--rat L6 myoblast heterokaryons. The globin mRNA is polyadenylylated and is translated into adult chicken alpha A-, alpha D-, and beta-globin polypeptides. No fetal globin mRNA or globin polypeptides were detected. Heterokaryons between chicken erythrocytes and mouse neuroblastoma cells or hamster BHK cells also synthesized adult chicken globins.

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