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Sweat Gland Duct Cells in Lafora Disease: Diagnosis by Skin Biopsy

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Journal Neurology
Specialty Neurology
Date 1981 Dec 1
PMID 6796905
Citations 22
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Abstract

Skin biopsies of three patients with Lafora disease (clinically typical and proven by liver biopsy) showed PAS-positive inclusions in numerous peripheral cells of eccrine sweat ducts. By electronmicroscopy, the inclusions consisted of polyglucosan-type material; they were not bounded by a membrane. Skin biopsy should be a convenient method of diagnosing Lafora disease.

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