Gestational Caffeine Modifies Offspring Behaviour in Mice

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1981 Jan 1

PMID 6795664

Citations 2

Authors

C M Sinton

J L Valatx

M Jouvet

Affiliations

Soon will be listed here.

Abstract

Dams from two strains of mice, BALB/c C57BR were tested during gestation with caffeine, at doses of about 60, 80 and 100 mg/kg/day, in their drinking water. The resulting offspring were behaviourally tested over a 6-month period commencing at age 9 months. When compared with controls, mice from dams that had received caffeine demonstrated longer latencies in a passive avoidance test, and differences were also noted for female C57BR offspring in activity and habituation measures. Having controlled as far as possible for post-natal maternal and environmental effects, the most likely conclusion is that caffeine has a direct pharmacological action on the foetus, and should therefore be classed as a behavioural teratogen in mice.

Citing Articles

Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine.

Laureano-Melo R, da Silveira A, Seara F, Conceicao R, Silva-Almeida C, Marinho B Metab Brain Dis. 2016; 31(5):1071-80.

PMID: 27262967 DOI: 10.1007/s11011-016-9847-5.

Long-lasting tolerance to stimulatory effects of perinatal caffeine treatment.

Lombardelli G, Balduini W, Feduzi A, Peruzzi G, Cattabeni F Psychopharmacology (Berl). 1984; 84(2):285-6.

PMID: 6438691 DOI: 10.1007/BF00427461.

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