High-density Lipoprotein Cholesterol and Apolipoprotein A-I Levels at Diagnosis in Patients with Non-insulin Dependent Diabetes

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1981 May 1

PMID 6793437

Citations 6

Authors

K G Taylor

A D Wright

T J Carter

A J Valente

S A Betts

K A Matthews

Affiliations

Soon will be listed here.

Abstract

High-density lipoprotein (HDL) cholesterol levels were decreased in patients with non-insulin dependent diabetes at diagnosis when matched with a control population for sex, age, obesity, alcohol consumption and cigarette smoking. There was no association between serum HDL-cholesterol concentration and the percentage of glycosylated haemoglobin A1 (HbA1). Serum HDL-cholesterol levels were lower in diabetics over the whole range of serum triglyceride levels, and particularly in hyper-triglyceridaemic diabetics. Serum apolipoprotein A-I levels were not decreased in diabetics with normal serum triglyceride levels, so that the ratio of HDL-cholesterol to apolipoprotein A-I was significantly decreased in diabetics (p Less Than 0.005). Decreased HDL-cholesterol levels in non-insulin dependent diabetes could be relevant to the subsequent development of atherosclerosis.

Citing Articles

Dietary effects on very low-density lipoproteins in type 2 (non-insulin-dependent) diabetes mellitus.

Weisweiler P, Drosner M, Schwandt P Diabetologia. 1982; 23(2):101-3.

PMID: 7128963 DOI: 10.1007/BF01271168.

The effect of intensive dietary therapy on serum high density lipoprotein cholesterol in patients with Type 2 (non-insulin-dependent) diabetes mellitus: a prospective study.

Kennedy L, Walshe K, Hadden D, Weaver J, Buchanan K Diabetologia. 1982; 23(1):24-7.

PMID: 7117725 DOI: 10.1007/BF00257725.

A prospective study of the effect of 12 months treatment on serum lipids and apolipoproteins A-I and B in Type 2 (non-insulin-dependent) diabetes.

Taylor K, John W, Matthews K, Wright A Diabetologia. 1982; 23(6):507-10.

PMID: 6818080 DOI: 10.1007/BF00254300.

Lipids, lipoproteins and apolipoproteins in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus.

Bittolo Bon G, Cazzolato G, AVOGARO P Acta Diabetol Lat. 1984; 21(4):315-24.

PMID: 6528791 DOI: 10.1007/BF02582084.

Sulphonylurea antidiabetic drugs. An update of their clinical pharmacology and rational therapeutic use.

Melander A, Bitzen P, Faber O, Groop L Drugs. 1989; 37(1):58-72.

PMID: 2651086 DOI: 10.2165/00003495-198937010-00004.

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