» Articles » PMID: 6785807

Effects of Lithium Carbonate on Methylphenidate-induced Mood, Behavior, and Cognitive Processes

Overview
Specialty Pharmacology
Date 1981 Jan 1
PMID 6785807
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Evidence is presented which suggests that lithium modifies the mood and behavioral alterations resulting from IV methylphenidate. Specifically, lithium significantly reduces the level of arousal-activation, euphoria-grandiosity, and the total score of manic-state ratings following a methylphenidate challenge. In addition, lithium appears to be capable of modifying the growth hormone response to methylphenidate.

Citing Articles

Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens.

Can A, Frost D, Cachope R, Cheer J, Gould T J Neurochem. 2016; 139(4):576-585.

PMID: 27513916 PMC: 5118071. DOI: 10.1111/jnc.13769.


Molecular actions and clinical pharmacogenetics of lithium therapy.

Can A, Schulze T, Gould T Pharmacol Biochem Behav. 2014; 123:3-16.

PMID: 24534415 PMC: 4220538. DOI: 10.1016/j.pbb.2014.02.004.


The behavioral actions of lithium in rodent models: leads to develop novel therapeutics.

ODonnell K, Gould T Neurosci Biobehav Rev. 2007; 31(6):932-62.

PMID: 17532044 PMC: 2150568. DOI: 10.1016/j.neubiorev.2007.04.002.


Chronic lithium attenuates dopamine D1-receptor mediated increases in acetylcholine release in rat frontal cortex.

Acquas E, Fibiger H Psychopharmacology (Berl). 1996; 125(2):162-7.

PMID: 8783390 DOI: 10.1007/BF02249415.


Separate mechanisms for behavioral, cardiovascular, and hormonal responses to dextroamphetamine in man.

Nurnberger Jr J, Kessler L, Jimerson S, Schreiber J, Hollander E, Tamminga C Psychopharmacology (Berl). 1984; 84(2):200-4.

PMID: 6239300 DOI: 10.1007/BF00427446.


References
1.
Rees L, Butler P, Gosling C, Besser G . Adrenergic blockade and the corticosteroid and growth hormone responses to methylamphetamine. Nature. 1970; 228(5271):565-6. DOI: 10.1038/228565a0. View

2.
Janowsky D, Davis J . Methylphenidate, dextroamphetamine, and levamfetamine. Effects on schizophrenic symptoms. Arch Gen Psychiatry. 1976; 33(3):304-8. DOI: 10.1001/archpsyc.1976.01770030024003. View

3.
Judd L, Hubbard B, Janowsky D, Huey L, Attewell P . The effect of lithium carbonate on affect, mood, and personality of normal subjects. Arch Gen Psychiatry. 1977; 34(3):346-51. DOI: 10.1001/archpsyc.1977.01770150104012. View

4.
Faraj B, Israili Z, Perel J, Jenkins M, Holtzman S, CUCINELL S . Metabolism and disposition of methylphenidate-14C: studies in man and animals. J Pharmacol Exp Ther. 1974; 191(3):535-47. View

5.
Wald D, Ebstein R, Belmaker R . Haloperidol and lithium blocking of the mood response to intravenous methylphenidate. Psychopharmacology (Berl). 1978; 57(1):83-7. DOI: 10.1007/BF00426962. View