Effects of Lithium Carbonate on Methylphenidate-induced Mood, Behavior, and Cognitive Processes
Overview
Affiliations
Evidence is presented which suggests that lithium modifies the mood and behavioral alterations resulting from IV methylphenidate. Specifically, lithium significantly reduces the level of arousal-activation, euphoria-grandiosity, and the total score of manic-state ratings following a methylphenidate challenge. In addition, lithium appears to be capable of modifying the growth hormone response to methylphenidate.
Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens.
Can A, Frost D, Cachope R, Cheer J, Gould T J Neurochem. 2016; 139(4):576-585.
PMID: 27513916 PMC: 5118071. DOI: 10.1111/jnc.13769.
Molecular actions and clinical pharmacogenetics of lithium therapy.
Can A, Schulze T, Gould T Pharmacol Biochem Behav. 2014; 123:3-16.
PMID: 24534415 PMC: 4220538. DOI: 10.1016/j.pbb.2014.02.004.
The behavioral actions of lithium in rodent models: leads to develop novel therapeutics.
ODonnell K, Gould T Neurosci Biobehav Rev. 2007; 31(6):932-62.
PMID: 17532044 PMC: 2150568. DOI: 10.1016/j.neubiorev.2007.04.002.
Acquas E, Fibiger H Psychopharmacology (Berl). 1996; 125(2):162-7.
PMID: 8783390 DOI: 10.1007/BF02249415.
Nurnberger Jr J, Kessler L, Jimerson S, Schreiber J, Hollander E, Tamminga C Psychopharmacology (Berl). 1984; 84(2):200-4.
PMID: 6239300 DOI: 10.1007/BF00427446.