Changes Induced by Vascular Antigens in the Aorta of Guinea-pigs: Immunological and Morphological Studies

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1978 Jun 1

PMID 678441

Citations 2

Authors

J Feher

M Horvath

E Feher

E Szondy

K Onody

S Gero

Affiliations

Soon will be listed here.

Abstract

The effects have been studied of human vessel wall on the cell-mediated and humoral immune response, as well as the morphological changes produced in the aorta in guinea-pigs. In animals immunized with calcium chloride-tris-citrate extracts of the aortic and vessel wall a definite cell-mediated and humoral immune response was observed. A cross-reaction was found between the 2 vessel wall extracts in the skin test and in the migration inhibition test. The induction of desoxyribonucleic acid synthesis was found to be specific. Antibody production as well as the concentration of IgG in the serum was increased. Simultaneously with increased production of the antibodies the cellular immune response did not diminish util the 9th week. A definite alteration was found in the aortic intima by histological, histochemical, immunofluorescence and electron microscopic methods. In addition some slight changes could be observed in the media and in the aventitia of the aorta.

Citing Articles

Takayasu's arteritis (pulseless disease) in Uganda.

Kalungi S, Kigonya E, Eyoku S, Atwine D, Kavuma J, Sebatta E Afr Health Sci. 2005; 4(3):185-7.

PMID: 15687072 PMC: 2688324.

The effect of autologous serum, Oradexon and heparin on the cell-mediated immune response in vascular diseases.

Horvath M, Szondy E, Ladanyi A Clin Exp Immunol. 1980; 41(3):521-6.

PMID: 7438565 PMC: 1537050.

References

Foad B, Adams L, Litwin A, Hess E . Peripheral blood lymphocyte response to phytomitogens in systemic lupus erythematosus. Ann Rheum Dis. 1975; 35(5):407-14. PMC: 1006572. DOI: 10.1136/ard.35.5.407. View

Allison A, DENMAN A, Barnes R . Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet. 1971; 2(7716):135-40. DOI: 10.1016/s0140-6736(71)92306-3. View

Miller J, Smith M, Mitchell C, REED W, Eddleston A, Williams R . Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet. 1972; 2(7772):296-7. DOI: 10.1016/s0140-6736(72)92904-2. View

Feher J, Jakab L, Szilvasi I . Immunoglobulins, glycoproteids and Australia antigen in chronic liver disease. Acta Med Acad Sci Hung. 1973; 30(3):197-203. View

FLOERSHEIM G . Induction of unresponsiveness to skin and heart allografts in mice by a synergistic treatment with procarbazine, antilymphocyte serum, and donor-type cells. Transplantation. 1973; 15(2):195-205. DOI: 10.1097/00007890-197302000-00002. View

Walton K, Williamson N . Histological and immunofluorescent studies on the evolution of the human atheromatous plaque. J Atheroscler Res. 1968; 8(4):599-624. DOI: 10.1016/s0368-1319(68)80020-1. View

Feher J, Bihari-Varga M, Varsanyi M, Gero S . The effect of clofibrate on cholesterol induced aortic lesions. Br J Exp Pathol. 1972; 53(5):509-17. PMC: 2072480. View

Petranyi G, Klein E, Svedmyr E, Jacobsson H . Guinea pigs immunized with xenogeneic cells: skin test, in vitro stimulation; cytotoxicity of lymph node cells. Cell Immunol. 1973; 9(1):157-62. DOI: 10.1016/0008-8749(73)90176-7. View

WARTENBERG J, Doniach D, Brostoff J, Roitt I . Leucocyte migration inhibition with mitochondria in human autoimmune thyroid disorders. Clin Exp Immunol. 1973; 14(2):203-12. PMC: 1553797. View

10.

Mancini G, Carbonara A, Heremans J . Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965; 2(3):235-54. DOI: 10.1016/0019-2791(65)90004-2. View

11.

Berry H, Bacon P, Davis J . Cell-mediated immunity in Sjögren's syndrome. Ann Rheum Dis. 1972; 31(4):298-302. PMC: 1005929. DOI: 10.1136/ard.31.4.298. View

12.

DAVIES D . Hypothesis. An immunological view of atherogenesis. J Atheroscler Res. 1969; 10(2):253-9. DOI: 10.1016/s0368-1319(69)80013-x. View

13.

RANNIE I, DUGUID J . The pathogenesis of cholesterol arteriosclerosis in the rabbit. J Pathol Bacteriol. 1953; 66(2):395-8. DOI: 10.1002/path.1700660210. View

14.

Gero S, Gergely J, Jakab L, Szekely J, VIRAG S, Farkas K . Inhibition of cholesterol atherosclerosis by immunisation with beta-lipoprotein. Lancet. 1959; 2(7088):6-7. DOI: 10.1016/s0140-6736(59)92108-7. View

15.

SVEJCAR J, JOHANOVSKY J . Demonstration of delayed (tuberculin) type hypersensitivity in vitro. I. Selection of methods. Z Immun exp ther. 1961; 122:398-419. View

16.

David J, AL-ASKARI S, LAWRENCE H, Thomas L . DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS. J Immunol. 1964; 93:264-73. View

17.

Nerup J, Andersen V, BENDIXEN G . Anti-adrenal cellular hypersensitivity in Addison's disease. IV. In vivo and in vitro investigations on the mitochondrial fraction. Clin Exp Immunol. 1970; 6(5):733-9. PMC: 1712730. View

18.

Mathews J, Whittingham S, Mackay I . Autoimmune mechanisms in human vascular disease. Lancet. 1974; 2(7894):1423-7. DOI: 10.1016/s0140-6736(74)90077-4. View

19.

Bihari-Varga M, Simon J, Feher J, Gero S . Thermal investigations on structural glycosaminoglycans and proteins. 2. The influence of atherosclerosis on the thermal decomposition of aortic intima. Acta Biochim Biophys Acad Sci Hung. 1969; 4(3):279-85. View

20.

Calder E, McLeman D, Barnes E, Irvine W . The effect of thyroid antigens on the in vitro migration of leucocytes from patients with Hashimoto thyroiditis. Clin Exp Immunol. 1972; 12(4):429-38. PMC: 1553603. View