Dynamic Changes in Acid Base Balance During Heatstroke in Dogs

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1980 Nov 1

PMID 6779263

Citations 1

Authors

A Magazanik

Y Shapiro

S SHIBOLET

Affiliations

Soon will be listed here.

Abstract

The dynamic changes in acid base balance and respiratory metabolism during the development of heatstroke in dogs were studied. Three groups of five unanesthetized dogs each were exposed to different climatic conditions while at rest: A) 24 degrees C, 50% relative humidity (RH); B) 35 degrees C, 35% RH, and C) 45 degrees C , 25% RH. These conditions were maintained for 4 h or until the dogs collapsed. The heatstroke dogs were cooled in tap water bathes and were observed for another 4 h. Dogs of groups A and B did not show any notable changes in rectal temperature (Tre) and acid base balance. All dogs in group C developed heatstroke. Their peak mean Tre (44.1 degrees C) was reached after a mean of 111 min of exposure, with respiratory alkalosis followed by increasingly severe metabolic acidosis above Tre of 42 degrees C. At peak Tre mean arterial pH was 7.26. Acidosis increased (pHa = 7.17) following cooling, as panting subsided. At Tre above 42 degrees C blood lactate increased and bicarbonate decreased significantly, attaining mean values of 58 mg% and 8 mEq/l, respectively. Bicarbonate changes correlated linearly with lactate changes. During recovery lactate decreased and blood pH increased approximating normal by the end of the experiment. The results illustrate the body's ability to spontaneously correct arterial pH without therapeutic means.

Citing Articles

Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke.

Shen K, Chang C, Lin M, Chang C Eur J Appl Physiol. 2008; 103(5):561-8.

PMID: 18458937 DOI: 10.1007/s00421-008-0755-1.

References

Danielson B, GRANGSJO G, Karlmark B, ULFENDAHL H, Wolgast M . Acid-base status in dogs during long term anaesthesia. Ups J Med Sci. 1975; 80(2):77-82. DOI: 10.3109/03009737509178997. View

Higgins E, IAMPIETRO P . Thermal panting and the initiation of respiratory alkalosis. Can J Physiol Pharmacol. 1967; 45(1):1-12. DOI: 10.1139/y67-001. View

Gronert G, THEYE R . Halothane-induced porcine malignant hyperthermia: metabolic and hemodynamic changes. Anesthesiology. 1976; 44(1):36-43. DOI: 10.1097/00000542-197601000-00008. View

FRANKEL H, CAIN S . Arterial and cerebral venous blood substrate concentrations during hyperthermia. Am J Physiol. 1966; 210(6):1265-8. DOI: 10.1152/ajplegacy.1966.210.6.1265. View

FRANKEL H, ELLIS Jr J, CAIN S . DEVELOPMENT OF TISSUE HYPOXIA DURING PROGRESSIVE HYPERTHERMIA IN DOGS. Am J Physiol. 1963; 205:733-7. DOI: 10.1152/ajplegacy.1963.205.4.733. View

Britt B . Editorial: Malignant hyperthermia: a pharmacogenetic disease of skeletal and cardiac muscle. N Engl J Med. 1974; 290(20):1140-2. DOI: 10.1056/NEJM197405162902012. View

Albers C, Usinger W, Scholand C . Intracellular pH in unanesthetized dogs during panting. Respir Physiol. 1975; 23(1):59-70. DOI: 10.1016/0034-5687(75)90072-9. View

GAMBLE Jr J, Bettice J . Acid-base relationships in the different body compartments: the basis for a simplified diagnostic approach. Johns Hopkins Med J. 1977; 140(5):213-21. View

GORDON E . Etiology of lactic acidosis. Am J Med Sci. 1973; 265(6):463-5. View

10.

Danielson B, GRANGSJO G, ULFENDAHL H, Wolgast M . Renal function in the dog in acute disturbances of the acid-base balance. Acta Anaesthesiol Scand. 1973; 17(2):88-102. DOI: 10.1111/j.1399-6576.1973.tb00803.x. View

11.

Wang J, MOFFITT E, ROSEVEAR J . Oxidative phosphorylation in acute hyperthermia. Anesthesiology. 1969; 30(4):439-42. DOI: 10.1097/00000542-196904000-00015. View

12.

Richards S . The biology and comparative physiology of thermal panting. Biol Rev Camb Philos Soc. 1970; 45(2):223-64. DOI: 10.1111/j.1469-185x.1970.tb01631.x. View

13.

Allen W, Patterson D, HARDING J, Berrett S . Experimentally induced acute stress syndrome in Pietrain pigs. Vet Rec. 1970; 87(3):64-9. DOI: 10.1136/vr.87.3.64. View

14.

Christopherson R, Webster A . Changes during eating in oxygen consumption, cardiac function and body fluids of sheep. J Physiol. 1972; 221(2):441-57. PMC: 1331342. DOI: 10.1113/jphysiol.1972.sp009760. View

15.

Sinha R, TINKER M, Hizon R, GERST P . Metabolic acidosis and lung mechanics in dogs to simulate a clinical condition. Am Rev Respir Dis. 1972; 106(6):881-91. DOI: 10.1164/arrd.1972.106.6.881. View

16.

Folts J . Preparation of a chronic indwelling catheter using a commercial infant feeding tube. J Appl Physiol. 1971; 30(3):417-9. DOI: 10.1152/jappl.1971.30.3.417. View

17.

Williams C, Houchins C, Shanklin M . Pigs susceptible to energy metabolism in the fulminant hyperthermia stress syndrome. Br Med J. 1975; 3(5980):411-3. PMC: 1673847. DOI: 10.1136/bmj.3.5980.411. View

18.

Magazanik A, Shapiro Y, SOHAR E . A simple breathing mask for dogs. J Appl Physiol. 1973; 34(1):112-5. DOI: 10.1152/jappl.1973.34.1.112. View

19.

Shapiro Y, Rosenthal T, SOHAR E . Experimental heatstroke. A model in dogs. Arch Intern Med. 1973; 131(5):688-92. View

20.

GONZALEZ N, Kelling E, Strome D, Clancy R . Cardiac and skeletal muscle acid-base composition during metabolic acidosis in dogs. Respir Physiol. 1976; 26(1):1-10. DOI: 10.1016/0034-5687(76)90047-5. View