Potential Therapeutic Applications of Aspirin and Other Cyclo-oxygenase Inhibitors

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1980 Oct 1

PMID 6776977

Citations 7

Authors

A E FARAH

F Rosenberg

Affiliations

Soon will be listed here.

Abstract

1 The ubiquitous actions of the cyclo-oxygenase inhibitors are described. 2 These include the inhibitory effect on prostaglandin synthesis and the direct effect of aspirin on lymphocytes and their ability to produce lymphokines. 3 Aspirin reduces some types of platelet aggregation possibly involving inhibition of the precursors of thromboxane A2 and prostacyclin. 4 The therapeutic implications in relation to transient ischaemic attacks, coronary artery disease and reno-allograft rejection are discussed. 5 The beneficial and adverse effects on the gastro-intestinal tract are described. 6 The effects of aspirin-like drugs on the genito-urinary tract are described with particular reference to their adverse effects on labour and their therapeutic effect on dysmenorrhoea.

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