Histopathological Modifications Following Immunotherapy with P 40 in Rats Bearing DMBA-induced Mammary Carcinoma

Overview

Journal Experientia

Specialty Science

Date 1980 Oct 15

PMID 6774883

Authors

K H HOLLMANN

J M VERLEY

Affiliations

Soon will be listed here.

Abstract

Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RES, and particularly a more intense reaction in the draining lymph nodes, than systemic treatment.

References

Woodruff M, Dunbar N . Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma. Br J Cancer. 1975; 32(1):34-41. PMC: 2024788. DOI: 10.1038/bjc.1975.131. View

Likhite V . Experimental cancer immunotherapy: comparison of tumor rejection if F344 rats given live Mycobacterium bovis (Strain BCG) and killed Corynebacterium parvum. J Natl Cancer Inst. 1976; 56(5):985-9. DOI: 10.1093/jnci/56.5.985. View

Scott M . Corynebacterium parvum as a therapeutic antitumor agent in mice. II. Local injection. J Natl Cancer Inst. 1974; 53(3):861-5. DOI: 10.1093/jnci/53.3.861. View

Greager J, Baldwin R . Influence of immunotherapeutic agents on the progression of spontaneously arising, metastasizing rat mammary adenocarcinomas of varying immunogenicities. Cancer Res. 1978; 38(1):69-73. View

Purnell D, Otterstrom J, Bartlett G, KREIDER J . Antitumor activity of killed Corynebacterium parvum suspensions in a murine mammary adenocarcinoma CaD2) system. J Natl Cancer Inst. 1976; 56(6):1171-5. DOI: 10.1093/jnci/56.6.1171. View

Fisher B, Gebhardt M, Linta J, Saffer E . Comparison of the inhibition of tumor growth following local or systemic administration of Corynebacterium parvum or other immunostimulating agents with or without cyclophosphamide. Cancer Res. 1978; 38(9):2679-87. View

Huggins C, Grand L, Brillantes F . Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression. Nature. 1961; 189:204-7. DOI: 10.1038/189204a0. View

Likhite V . Rejection of tumors and metastases in Fischer 344 rats following intratumor administration of killed Corynebacterium parvum. Int J Cancer. 1974; 14(5):684-90. DOI: 10.1002/ijc.2910140516. View

KREIDER J, Bartlett G, Purnell D, Webb S . Immunotherapy of an established rat mammary adenocarcinoma (13762A) with intratumor injection of Corynebacterium parvum. Cancer Res. 1978; 38(3):689-92. View

10.

Hanna Jr M, Zbar B, Rapp H . Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. I. Tumor growth and metastasis. J Natl Cancer Inst. 1972; 48(5):1441-55. View

11.

Rosenberg S, Rapp H . Intralesional immunotherapy of melanoma with BCG. Med Clin North Am. 1976; 60(3):419-30. DOI: 10.1016/s0025-7125(16)31889-2. View

12.

Snodgrass M, Hanna Jr M . Ultrastructural studies of histiocyte-tumor cell interactions during tumor regression after intralesional injection of Mycobacterium bovis. Cancer Res. 1973; 33(4):701-16. View

13.

Scott M . Corynebacterium parvum as a therapeutic antitumor agent in mice. I. Systemic effects from intravenous injection. J Natl Cancer Inst. 1974; 53(3):855-60. DOI: 10.1093/jnci/53.3.855. View