Interactions of Chlordiazepoxide and Anorectic Agents on Rate and Duration Parameters of Feeding in the Rat

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1980 Jan 1

PMID 6774364

Citations 3

Authors

S J Cooper

R L FRANCIS

Affiliations

Soon will be listed here.

Abstract

d-Amphetamine (0.5 and 1.0 mg/kg) and dl-fenfluramine (2.0 and 4.0 mg/kg) reduced food intake in a short exposure feeding test, and their effects were counteraated by chloriazepoxide, particularly at 50 mg/kg. Chloriazepoxide reduced latency to eat, extended the durationof feeding and depressed the rate of feeding. Antagonism occurred in combination with d-amphetamine in relation to latency and duration, but in this experiment d-amphetamine did not affect feeding rate. Antagonism also occurred in combination with fenfluramine, with latency and duration measures, but only at the lower chlordiazepoxide dose. Instead, chlordiazepoxide (10.0 mg/kg) enhanced fenfluramine's effects to reduce feeding duration and feeding rate.

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