Histology of the Intestinal Peritoneum in Patients with Cirrhosis of the Liver and Ascites

Overview

Journal Am J Dig Dis

Specialty Gastroenterology

Date 1978 May 1

PMID 677092

Citations 1

Authors

I BUHAC

J JARMOLYCH

Affiliations

Soon will be listed here.

Abstract

Portal hypertension and hypoalbuminemia are usually incriminated in the development of ascites in liver cirrhosis, and altered peritoneal permeability is considered only as a hypothetical possibility. Jejunal postmortem specimens were studied in 15 control patients and 16 patients dying with cirrhosis of the liver and ascites. In decompensated cirrhosis a fibrous thickening of the peritoneum was found, 159.0 +/- 96.4 micrometer (mean +/- SD) compared to 24.5 +/- 10.6 micrometer in controls (P less than 0.001). An increase in the size and number of blood vessels, lymphangiectasiae, and mononuclear cell infiltration were invariably present. These histological changes are consistent with a nonspecific chronic peritonitis. The findings indicate there is increased blood perfusion and lymph flow within the intestinal peritoneum in patients with decompensated cirrhosis of the liver and support the existence of an intestinal peritoneal factor in the pathogenesis of cirrhotic ascites.

Citing Articles

Sclerosing peritonitis.

Lee R Dig Dis Sci. 1989; 34(9):1473-6.

PMID: 2766916 DOI: 10.1007/BF01538089.

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