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Dose-dependent Effects of Heroin on Memory in Two Inbred Strains of Mice

Overview
Journal Psychopharmacology (Berl)
Specialty Pharmacology
Date 1980 Jan 1
PMID 6770401
Citations 6
Authors
C Castellano
Affiliations
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Abstract

Heroin was administered to DBA/2 and C57BL/6 mice, trained in the five-choice Yerkes-Thompson-Bryant-Bovet-Nitti apparatus for pattern discrimination, in two sets of experiments. In a first set, pretrial administrations of heroin (0.1, 0.25, or 0.5 mg/kg) improved performance in both strains. In a second set, heroin (0.5 mg/kg) immediately following each training session were followed by performance improvements in both strains, while the performance of C57 mice was improved and that of the DBA mice was impaired by 5 mg/kg of opiate. No effect was evident in this set of experiments when heroin was injected 2 h after each session, suggesting that effects of the pretrial treatments were due to influences of the opiate on the consolidation processes of the strains tested.

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References
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Castellano C, Filibeck L, Oliverio A . Effects of heroin, alone or in combination with other drugs, on the locomotor activity in two inbred strains of mice. Psychopharmacology (Berl). 1976; 49(1):29-31. DOI: 10.1007/BF00427467. View
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Castellano C . Effects of pre- and post-trial caffeine administrations on simultaneous visual discrimination in three inbred strains of mice. Psychopharmacology (Berl). 1977; 51(3):255-8. DOI: 10.1007/BF00431632. View
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Castellano C . Effects of mescaline and amphetamine on simultaneous visual discrimination in two inbred strains of mice. Psychopharmacology (Berl). 1979; 62(1):35-40. DOI: 10.1007/BF00426032. View
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Castellano C . Effects of morphine and heroin on discrimination learning and consolidation in mice. Psychopharmacologia. 1975; 42(3):235-42. DOI: 10.1007/BF00421262. View