The Effect of Uraemic "middle-sized Molecules" on T Lymphocyte Functions

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 1980 Jan 1

PMID 6763010

Citations 1

Authors

K Kalman

L Locsey

M Hauck

A Leovey

Affiliations

Soon will be listed here.

Abstract

The activity of the leucocyte inhibitory factor (LIF) stimulated with Concanavalin A was examined in chronic uraemic, haemodialysed patients. It was found that the LIF activity decreased in chronic uraemic patients as compared with the normal controls. The absolute T lymphocyte count and active E rosette formation also decreased. In in vitro experiments the authors have also examined the inhibitory effect of the so-called "middle-sized molecule" (MSM) on uraemic materials separated from the serum and the haemofiltrate. They observed that the materials with a molecular weight of 1000-1500 isolated both from the serum and the haemofiltrate significantly inhibited the Con A stimulated LIF production of normal lymphocytes and decreased the ratio of the active E rosette-forming T lymphocytes. On the basis of their experiments the MSM uraemic materials are considered responsible for the decreased immune reactivity of uraemic patients. These uraemic toxins can be dialysed.

Citing Articles

Protein-Bound Uremic Toxins and Immunity.

Rocchetti M, Cosola C, Ranieri E, Gesualdo L Methods Mol Biol. 2021; 2325:215-227.

PMID: 34053061 DOI: 10.1007/978-1-0716-1507-2_15.

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