Mutagenesis in Cdc7 Strains of Yeast. The Fate of Premutational Lesions Induced by Ultraviolet Light

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1982 Nov 1

PMID 6755238

Citations 5

Authors

G D Njagi

B J Kilbey

Affiliations

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Abstract

cdc7-1 cells bearing UV-revertible mutations are virtually immutable by all means so far tested. By mating UV treated cdc7-1 cells with untreated cdc7+ cells carrying the same revertible alleles it is possible to rescue premutational lesions as revertants and to study their fate in cdc7-1 cells. If storage intervenes between treatment and mating there is a rapid decline in revertants rescued. This is not related to the death of cdc7-1 cells with storage nor does it reflect a progressive loss in their ability to mate.

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