Immunogenetic Aspects of in Vivo Allotolerance Induction During the Ontogeny of Xenopus Laevis

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1982 Jan 1

PMID 6754587

Citations 3

Authors

S J DiMarzo

N Cohen

Affiliations

Soon will be listed here.

Abstract

This study describes the ontogeny of allograft immunity in a partially inbred strain of frogs (Xenopus laevis). At various times during the frogs' premetamorphic, perimetamorphic, and postmetamorphic life, major histocompatibility complex (MHC) homozygous strain JJ Xenopus (MHC haplotype j) were grafted with skin from adult donors of defined MHC homozygous (j,f) and heterozygous (j/f,f/h) haplotypes. This protocol reveals that destructive allograft reactivity to MHC alloantigens in Xenopus matures slowly and that allotolerance can be induced to such MHC-encoded antigens throughout larval life. The ultimate fate of an MHC disparate transplant (survival or rejection) is dependent on several interacting variables, which include antigen dose, haplotype dose, and the developmental stage of the host frog at the time of transplantation. In contrast, minor H-locus disparate (MHC compatible) grafts never appear to be rejected by hosts grafted at any larval stage.

Citing Articles

Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs.

De Jesus Andino F, Chen G, Li Z, Grayfer L, Robert J Virology. 2012; 432(2):435-43.

PMID: 22819836 PMC: 3574294. DOI: 10.1016/j.virol.2012.07.001.

The genus Xenopus as a multispecies model for evolutionary and comparative immunobiology of the 21st century.

Robert J, Cohen N Dev Comp Immunol. 2011; 35(9):916-23.

PMID: 21277325 PMC: 3109137. DOI: 10.1016/j.dci.2011.01.014.

Comparative and developmental study of the immune system in Xenopus.

Robert J, Ohta Y Dev Dyn. 2009; 238(6):1249-70.

PMID: 19253402 PMC: 2892269. DOI: 10.1002/dvdy.21891.

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