Postoperative Radiotherapy in Rectosigmoid Cancer Dukes' B and C: Interim Report from a Randomized Multicentre Study

Overview

Journal Br J Cancer

Specialty Oncology

Date 1982 Oct 1

PMID 6753912

Citations 4

Authors

I Balslev

M Pedersen

P S Teglbjaerg

J Bone

N O Jacobsen

J Overgaard

A Sell

K Bertelsen

E Hage

L Hansen

O Kronborg

H HOSTRUP

B Norgaard-Pedersen

Affiliations

Soon will be listed here.

Abstract

The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate-below 10% in 221 patients-permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90.

Citing Articles

Adjuvant therapy in colorectal cancer.

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Do synchronous adenomas influence prognosis after radical surgery for colorectal carcinoma? A prospective study.

Kronborg O, Hage E, Fenger C, Deichgraeber E Int J Colorectal Dis. 1986; 1(2):99-103.

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A regression analysis of prognostic factors after resection of Dukes' B and C carcinoma of the rectum and rectosigmoid. Does post-operative radiotherapy change the prognosis?.

Bentzen S, Balslev I, Pedersen M, Teglbjaerg P, Bone J, Jacobsen N Br J Cancer. 1988; 58(2):195-201.

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Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy. A multivariate regression analysis.

Bentzen S, Balslev I, Pedersen M, Teglbjaerg P, Bone J, Jacobsen N Br J Cancer. 1992; 65(1):102-7.

PMID: 1733432 PMC: 1977364. DOI: 10.1038/bjc.1992.19.

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