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Cdc7-1 a Temperature Sensitive Cell-cycle Mutant Which Interferes with Induced Mutagenesis in Saccharomyces Cerevisiae

Overview
Journal Mol Gen Genet
Specialties Genetics
Molecular Biology
Date 1982 Jan 1
PMID 6752657
Citations 36
Authors
G D Njagi
B J Kilbey
Affiliations
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Abstract

The mutant cdc7-1 is shown here to block UV induced reversion of six different auxotrophic mutations and forward mutations at several genes concerned with adenine biosynthesis in Saccharomyces cerevisiae. Chemical mutagenesis is also drastically reduced. In its effect on mutagenesis cdc7-1 resembles rad6-1. However, in contrast to rad6-1, cdc7-1 does not affect sporulation or mitotic recombination neither is it sensitive to the antifolate drug trimethoprim. It appears to fall in the same epistatic group as rad6-1. Possible explanations for its action are briefly considered.

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