Increase in Circulating Basement Membrane Antigens in Diabetic Rats and Effects of Insulin Treatment

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1982 Sep 1

PMID 6751906

Citations 12

Authors

J Risteli

K E Draeger

G Regitz

H P Neubauer

Affiliations

Soon will be listed here.

Abstract

The serum concentrations of two recently discovered antigens derived from basement membranes (7-S collagen and laminin P2) were assayed in streptozotocin-diabetic rats as possible indicators of basement membrane metabolism. The concentrations of both increased significantly after 8 weeks of diabetes, and that of 7-S collagen at least remained elevated up to 24 weeks. Treatment with insulin, which did not correct the metabolic disturbances, inhibited the increase in the concentration of 7-S collagen in serum, but did not completely normalize that of laminin P2.

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