Isolation of Amyloid P Component (protein AP) from Normal Serum As a Calcium-dependent Binding Protein

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1977 May 14

PMID 67487

Citations 41

Authors

M B Pepys

A C Dash

Affiliations

Soon will be listed here.

Abstract

The P component of amyloid (protein AP, pentagonal unit) has been isolated from normal serum by using its hitherto undescribed calcium-dependent affinity for agarose. The presence of P component in all forms of amyloid may be due to this calcium-dependent binding to certain polyanions.

Citing Articles

An overview on serum lectins.

Beulaja Manikandan S, Manikandan R, Arumugam M, Mullainadhan P Heliyon. 2020; 6(8):e04623.

PMID: 32923708 PMC: 7475231. DOI: 10.1016/j.heliyon.2020.e04623.

The Pentraxins 1975-2018: Serendipity, Diagnostics and Drugs.

Pepys M Front Immunol. 2018; 9:2382.

PMID: 30459761 PMC: 6232782. DOI: 10.3389/fimmu.2018.02382.

The Development of Serum Amyloid P as a Possible Therapeutic.

Pilling D, Gomer R Front Immunol. 2018; 9:2328.

PMID: 30459752 PMC: 6232687. DOI: 10.3389/fimmu.2018.02328.

Advances in Treatment of Cardiac Amyloid.

Dahm C, Cornell R, Lenihan D Curr Treat Options Cardiovasc Med. 2018; 20(5):37.

PMID: 29627865 DOI: 10.1007/s11936-018-0631-1.

Transthyretin Cardiac Amyloidosis in Black Americans.

Shah K, Mankad A, Castano A, Akinboboye O, Duncan P, Fergus I Circ Heart Fail. 2016; 9(6):e002558.

PMID: 27188913 PMC: 4874558. DOI: 10.1161/CIRCHEARTFAILURE.115.002558.