Acetylator Phenotyping: the Effect of Ethanol on the Dapsone Test

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1984 Jul 1

PMID 6743494

Citations 6

Authors

A Hutchings

R D Monie

B Spragg

P A Routledge

Affiliations

Soon will be listed here.

Abstract

In twelve healthy drug-free subjects (six slow acetylators), administration of alcohol (to achieve an ethanol concentration between 650 and 1180 mg 1(-1) ) did not significantly affect the ratio of monoacetyl dapsone (MADS) to dapsone (DDS) 3 h after oral dapsone (100 mg). We conclude that moderate acute ethanol consumption is unlikely to alter the acetylator phenotype measured by the dapsone test.

Citing Articles

The effects of acute ethanol intake on isoniazid pharmacokinetics.

Dattani R, Harry F, Hutchings A, Routledge P Eur J Clin Pharmacol. 2004; 60(9):679-82.

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Distribution of acetylator phenotype in relation to age and sex in Swedish patients. A retrospective study.

Paulsen O, Nilsson L Eur J Clin Pharmacol. 1985; 28(3):311-5.

PMID: 4007036 DOI: 10.1007/BF00543329.

The effect of glucose on acetylation status.

Suhardjono D, Boutagy J, Shenfield G Br J Clin Pharmacol. 1986; 22(4):401-8.

PMID: 3768255 PMC: 1401158. DOI: 10.1111/j.1365-2125.1986.tb02909.x.

Acetylation and oxidation phenotypes in malignant lymphoma.

Philip P, Rogers H, Harper P Cancer Chemother Pharmacol. 1987; 20(3):235-8.

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Clinical pharmacokinetics of dapsone.

Zuidema J, Merkus F Clin Pharmacokinet. 1986; 11(4):299-315.

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References

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