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Phosphorylation of Histones in Cells Treated with Hypertonic and Acidic Media

Overview
Journal Mol Cell Biol
Specialty Cell Biology
Date 1984 Jun 1
PMID 6738537
Citations 2
Authors
P Pantazis
M H West
W M Bonner
Affiliations
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Abstract

Factors in the extracellular environment, specifically hypertonic or acidic growth media, are shown to alter the modification of histones in several cell lines. For histone 2A, changes in modification were visible in the mass pattern and were found to be primarily changes in phosphorylation. The increased modification of the core histones was quickly reversed when cells were returned to normal medium.

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