PKa Determination of Verapamil by Liquid-liquid Partition

Overview

Journal J Pharm Sci

Publisher Elsevier

Specialties Pharmacology
Pharmacy

Date 1984 Apr 1

PMID 6726625

Citations 12

Authors

J Hasegawa

T Fujita

Y Hayashi

K Iwamoto

J Watanabe

Affiliations

Soon will be listed here.

Abstract

The pKa of verapamil was determined by measuring the partition coefficient of verapamil between n-heptane and aqueous buffer solution at various pH values. The magnitude of the effects of ionic strength or temperature on the pKa of verapamil was in agreement with those reported previously. The estimated pKa of verapamil in human plasma was 8.75. The pKa of 2,4,6-trimethylpyridine measured by means of the present partition method was in good agreement with that determined by UV spectrophotometry.

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