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A New Model of Glucocorticoid-induced Metanephric Maldevelopment

Overview
Journal Experientia
Specialty Science
Date 1984 May 15
PMID 6723915
Citations 3
Authors
E D Avner
W E Sweeney Jr
N P Piesco
D Ellis
Affiliations
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Abstract

A new experimental model of glucocorticoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4 X 10(-5) M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis . The model isolates the role of glucocorticoids in experimental cyst formation.

Citing Articles

Regression of genetically determined polycystic kidney disease in murine organ culture.

Avner E, Sweeney Jr W, Piesco N, Ellis D Experientia. 1986; 42(1):77-80.

PMID: 3943602 DOI: 10.1007/BF01975904.

Growth factor requirements of organogenesis in serum-free metanephric organ culture.

Avner E, Sweeney Jr W, Piesco N, Ellis D In Vitro Cell Dev Biol. 1985; 21(5):297-304.

PMID: 3894316 DOI: 10.1007/BF02620946.

Renal epithelial development in organotypic culture.

Avner E, Piesco N, Sweeney Jr W, Ellis D Pediatr Nephrol. 1988; 2(1):92-9.

PMID: 3153007 DOI: 10.1007/BF00870387.

References
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