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Single Base Deletion in the Vasopressin Gene is the Cause of Diabetes Insipidus in Brattleboro Rats

Overview
Journal Nature
Specialty Science
Date 1984 Apr 19
PMID 6717565
Citations 56
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Abstract

In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.

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