Enzymatic Repair of Premutagenic DNA Lesions in Human Epidermis. Quantitation of O6-methylguanine-DNA Methyltransferase and Uracil-DNA Glycosylase Activities

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1984 Mar 1

PMID 6717472

Citations 3

Authors

B Myrnes

G Eggset

G Volden

H Krokan

Affiliations

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Abstract

Extracts of human epidermis prepared by the suction blister method were used to measure O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activities. Although both activities were detected in all extracts examined, a 4-5-fold interindividual variation in activity was found. No obvious correlation of the two enzyme activities with the age of the patient was observed. Neither was there any correlation between the level of uracil-DNA glycosylase activity and O6-methylguanine-DNA methyltransferase activity.

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