Article: Trichloroethylene occupational exposure: elements for better prevention

One hundred and eighty-eight workers occupationally exposed to trichloroethylene (TRI) were studied by physical examination, exposure parameters (measure of atmospheric TRI and urinary trichloroacetic acid (CA) and evaluation of personal factors (age, alcoholic and tobacco consumption). A statistical comparison (chi 2 test) of the frequency of the symptoms observed in the high- and low-exposure populations with an analysis of nonprofessional factors allowed us to distinguish different classes of symptoms. Those more likely linked with TRI exposure are trigeminal and optic nerve impairment, asthenia, headache and dizziness. An interaction between TRI exposure and alcohol intake on the occurrence of clinical liver impairment and degreaser flush is suggested.

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References

1.

Barret L, Arsac P, Vincent M, Faure J, Garrel S, Reymond F . Evoked trigeminal nerve potential in chronic trichloroethylene intoxication. J Toxicol Clin Toxicol. 1982; 19(4):419-23. DOI: 10.3109/15563658208992496. View

2.

BARDODEJ Z, Vyskocil J . The problem of trichloroethylene in occupational medicine; trichloroethylene metabolism and its effect on the nervous system evaluated as a means of hygienic control. AMA Arch Ind Health. 1956; 13(6):581-92. View

3.

Lindstrom K . Changes in psychological performances of solvent-poisoned and solvent-exposed workers. Am J Ind Med. 1980; 1(1):69-84. DOI: 10.1002/ajim.4700010109. View

4.

LILIS R, Stanescu D, MUICA N, ROVENTA A . Chronic effects of trichloroethylene exposure. Med Lav. 1969; 60(10):595-601. View

5.

Muller G, Spassowski M, Henschler D . Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanol. Arch Toxicol. 1975; 33(3):173-89. DOI: 10.1007/BF00311271. View

6.

Huang C, Feely M . Trigeminal evoked potentials in the cat. Electroencephalogr Clin Neurophysiol. 1982; 54(1):63-70. DOI: 10.1016/0013-4694(82)90232-2. View

7.

Stewart R, HAKE C, Peterson J . "Degreaser's flush". Arch Environ Health. 1974; 29(1):1-5. DOI: 10.1080/00039896.1974.10666517. View

8.

Smith G . Trichlorethylene: a review. Br J Ind Med. 1966; 23(4):249-62. PMC: 1008464. View

9.

BUXTON P, Hayward M . Polyneuritis cranialis associated with industrial trichloroethylene poisoning. J Neurol Neurosurg Psychiatry. 1967; 30(6):511-8. PMC: 496241. DOI: 10.1136/jnnp.30.6.511. View

10.

GRANDJEAN E, MUNCHINGER R, TURRIAN V, HASS P, KNOEPFEL H, ROSENMUND H . Investigations into the effects of exposure to trichlorethylene in mechanical engineering. Br J Ind Med. 1955; 12(2):131-42. PMC: 1037620. DOI: 10.1136/oem.12.2.131. View

11.

Salvini M, Binaschi S, Riva M . Evaluation of the psychophysiological functions in humans exposed to trichloroethylene. Br J Ind Med. 1971; 28(3):293-5. PMC: 1069504. DOI: 10.1136/oem.28.3.293. View

12.

Feldman R, MAYER R, Taub A . Evidence for peripheral neurotoxic effect of trichloroethylene. Neurology. 1970; 20(6):599-606. DOI: 10.1212/wnl.20.6.599. View

Trichloroethylene Occupational Exposure: Elements for Better Prevention