Central Nervous System Involvement in Optic Neuritis

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1984 Mar 1

PMID 6707669

Citations 6

Authors

E A Sanders

J P Reulen

L A HOGENHUIS

Affiliations

Soon will be listed here.

Abstract

Thirty patients with clinically uncomplicated optic neuritis were subjected to a battery of electrophysiological tests, including visual evoked response (VER), auditory brainstem evoked response (ABER) and somatosensory evoked response (SSER). Blink reflex, electronystagmography (ENG), and computed tomography examinations were also carried out on all patients. These non-invasive tests indicated that in 11 of the 30 patients (37%), the optic neuritis was a symptom of subclinical multiple sclerosis, and that another five patients showed signs of mild central nervous system (CNS) involvement which may develop into multiple sclerosis later. This was confirmed by cerebrospinal fluid (CSF) analysis, using isoelectric focusing, showing oligoclonal extra bands in 11 out of these sixteen. A new classification of optic neuritis is proposed on the basis of these findings.

Citing Articles

Isolated optic neuritis and its prognosis for multiple sclerosis: a clinical and paraclinical study with evoked potentials. CSF examination and brain MRI.

Ghezzi A, Torri V, Zaffaroni M Ital J Neurol Sci. 1996; 17(5):325-32.

PMID: 8933225 DOI: 10.1007/BF01999894.

Optic neuritis: findings on MRI, CSF examination and HLA class II typing in 60 patients and results of a short-term follow-up.

Soderstrom M, Lindqvist M, Hillert J, Kall T, Link H J Neurol. 1994; 241(6):391-7.

PMID: 7931435 DOI: 10.1007/BF02033357.

Disseminated lesions at presentation in patients with optic neuritis.

Ormerod I, McDonald W, DU BOULAY G, Kendall B, Moseley I, Halliday A J Neurol Neurosurg Psychiatry. 1986; 49(2):124-7.

PMID: 3950632 PMC: 1028676. DOI: 10.1136/jnnp.49.2.124.

Computerised eye-movement processor for clinical applications: basic considerations and design.

Reulen J, van Heuningen R, Tiesinga G, Bos J Med Biol Eng Comput. 1986; 24(2):209-15.

PMID: 3713285 DOI: 10.1007/BF02443940.

Optic neuritis, confirmed by visual evoked response, and the risk for multiple sclerosis: a prospective survey.

Sanders E, Van Lith G J Neurol Neurosurg Psychiatry. 1989; 52(6):799-800.

PMID: 2746276 PMC: 1032040. DOI: 10.1136/jnnp.52.6.799-a.

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