Alpha 2.0
Login Register
» Articles » PMID: 669712

Evidence for a 'silent Allele' GLO0 at the Glyoxalase I Locus

Overview
Journal Hum Genet
Specialty Genetics
Date 1978 Jun 27
PMID 669712
Citations 7
Authors
C Rittner
W Weber
Affiliations
Soon will be listed here.
Abstract

In a three-generation family, the segregation of an apparent silent allele at the GLO I locus in association with the rare HLA haplotype 'AW30-CW4-BW35' was observed in four members. In two cases the assumption of homozygosity at the GLO locus would lead to mother-child exclusions. Phenotypically, the GLO activity in the GLO0 carriers is clearly diminished.

Citing Articles

A new variant glyoxalase I allele that is readily detectable in stimulated lymphocytes and lymphoblastoid cell lines but not in circulating lymphocytes or erythrocytes.

Kavathas P, Demars R Am J Hum Genet. 1981; 33(6):935-45.

PMID: 7325156 PMC: 1685144.

[Glyoxalase I polymorphisms: distribution of phenotypes and gene frequencies in Portugal (author's transl)].

Weissmann J, PRIBILLA O Z Rechtsmed. 1981; 86(3):205-11.

PMID: 7234136

Glyoxalase I "null" allele in a new family: identification by abnormal segregation pattern and quantitative assay.

Sparkes R, Sparkes M, Crist M, Anderson C Hum Genet. 1983; 64(2):146-7.

PMID: 6885048 DOI: 10.1007/BF00327112.

A new rare variant of the glyoxalase I system of the red cell: GLO-Sicily.

Beretta M, Schiliro G, Russo A, Barbujani G, Mazzetti P, Russo G Am J Hum Genet. 1983; 35(5):1042-7.

PMID: 6613997 PMC: 1685809.

[A new allele of AK-Polymorphism: AK0 (author's transl)].

Weissmann J, PRIBILLA O Z Rechtsmed. 1981; 87(4):261-5.

PMID: 6280410 DOI: 10.1007/BF00200640.

References
1.
Kuhnl P, Schwabenland R, SPIELMANN W . Investigations on the polymorphism of glyoxalase I (EC 4.4.1.5) in the population of Hessen, Germany. Hum Genet. 1977; 38(1):99-106. DOI: 10.1007/BF00295812. View
2.
Kompf J, Bissbort S, Gohler F, Schunter F, Wernet P . Map order of the linkage group GLO-Bf-HLA-A-PGM3 on human chromosome 6. Scand J Immunol. 1977; 6(5):453-7. DOI: 10.1111/j.1365-3083.1977.tb02102.x. View
3.
Weitkamp L . Linkage of GLO with HLA and Bf. Effect of population and sex on recombination frequency. Tissue Antigens. 1976; 7(5):273-9. DOI: 10.1111/j.1399-0039.1976.tb01068.x. View
4.
Olaisen B, Gedde-Dahl Jr T, Thorsby E . Localization of the human GLO gene locus. Hum Genet. 1976; 32(3):301-4. DOI: 10.1007/BF00295820. View
5.
Mayr W, Mayr D, Kompf J, Bissbort S, Ritter H . Possible linkage of HL-A and GLO. Hum Genet. 1976; 31(2):241-2. DOI: 10.1007/BF00296153. View