Therapeutic Efficacy of Tetrahydrobiopterin in Parkinson's Disease
Overview
Authors
Affiliations
Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.
Cronin S, Yu W, Hale A, Licht-Mayer S, Crabtree M, Korecka J bioRxiv. 2023; .
PMID: 37214873 PMC: 10197517. DOI: 10.1101/2023.05.08.539795.
Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry.
Fanet H, Capuron L, Castanon N, Calon F, Vancassel S Curr Neuropharmacol. 2020; 19(5):591-609.
PMID: 32744952 PMC: 8573752. DOI: 10.2174/1570159X18666200729103529.
Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase.
Yang S, Jan Y, Mishin V, Richardson J, Hossain M, Heindel N J Pharmacol Exp Ther. 2015; 352(3):529-40.
PMID: 25550200 PMC: 4352594. DOI: 10.1124/jpet.114.221572.
Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells.
Yang S, Jan Y, Gray J, Mishin V, Heck D, Laskin D J Biol Chem. 2013; 288(26):19221-37.
PMID: 23640889 PMC: 3696693. DOI: 10.1074/jbc.M112.402164.
Autophagy induction by tetrahydrobiopterin deficiency.
Kwak S, Suk J, Choi J, Yang S, Kim J, Sohn S Autophagy. 2011; 7(11):1323-34.
PMID: 21795851 PMC: 3242797. DOI: 10.4161/auto.7.11.16627.