Successful Small Bowel Allotransplantation in Dogs with Cyclosporine and Prednisone

Overview

Journal Transplantation

Specialty General Surgery

Date 1984 Feb 1

PMID 6695451

Citations 12

Authors

H S Diliz-Perez

J McClure

C Bedetti

H Q Hong

E de Santibanes

B W Shaw Jr

D Van Thiel

S Iwatsuki

T E Starzl

Affiliations

Soon will be listed here.

Abstract

Twelve dogs had transplantation of almost the entire small intestine in the orthotopic location; immunosuppression was with cyclosporine and prednisone. Half the dogs had survival of at least one month, and a third lived for at least four months. Two of the animals are still living after 550 and 555 days. Maintenance of nutrition, and absorption of D-xylose and fat were better than in control animals with an iatrogenic short gut syndrome, but distinctly worse than that of normal dogs.

Citing Articles

Immunomodulation for intestinal transplantation by allograft irradiation, adjunct donor bone marrow infusion, or both.

Murase N, Ye Q, Nalesnik M, Demetris A, Abu-Elmagd K, Reyes J Transplantation. 2001; 70(11):1632-41.

PMID: 11152226 PMC: 2972579. DOI: 10.1097/00007890-200012150-00016.

Absorptive function following small intestinal transplantation.

Kim J, Fryer J, CRAIG R Dig Dis Sci. 1998; 43(9):1925-30.

PMID: 9753253 DOI: 10.1023/a:1018816622510.

Functional aspects of small bowel transplantation: past, present, and future.

Meijssen M, Heineman E Gut. 1994; 35(10):1338-42.

PMID: 7959180 PMC: 1374998. DOI: 10.1136/gut.35.10.1338.

Gastrointestinal motility in the immediate postoperative period after intestinal transplantation, with special reference to acute rejection.

Ikoma A, Nakada K, Suzuki T, Nakamura K, Reynolds J, Todo S Transplant Proc. 1994; 26(3):1657-8.

PMID: 7913272 PMC: 2955407.

Pancreaticoduodenal transplantation in humans.

Starzl T, Iwatsuki S, Shaw Jr B, Greene D, Van Thiel D, Nalesnik M Surg Gynecol Obstet. 1984; 159(3):265-72.

PMID: 6382661 PMC: 2651198.

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