Methylbromide: Carcinogenic Effects in the Rat Forestomach

Overview

Journal Toxicol Appl Pharmacol

Specialties Pharmacology
Toxicology

Date 1984 Feb 1

PMID 6695375

Citations 8

Authors

L H Danse

F L van Velsen

C A van der Heijden

Affiliations

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Abstract

Methylbromide (MB) administered by oral gavage as a solution in arachis oil was carcinogenic to rats in a 90-day experiment. In 13 of 20 animals of the highest dose group, 50 mg MB/kg body wt squamous cell carcinomas of the forestomach developed. All animals of this group showed a marked diffuse hyperplasia of the epithelium of the forestomach. A less pronounced hyperplasia was observed in high and lower incidence with respectively 10 and 2 mg MB/kg body wt. The lowest dose, 0.4 mg MB/kg body wt was without effects.

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