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Estimation of the Methylating Capacity of the Pineal Gland. With Special Reference to Indole Metabolism

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Journal Experientia
Specialty Science
Date 1978 Jul 15
PMID 668861
Citations 17
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Abstract

In order to obtain more information on the methylating capacity of the pineal gland, a method determining the formation of different 5-methoxyindoles in the pineal gland was developed. The method depends on measuring the incorporation of labelled methyl groups into the various hydroxyindoles present in the pineal gland, after incorporation of pineal tissue with labelled S-adenosyl methionine. Hydroxyindoles were not added to the incubation medium. After incubation thin-layer chromatography was performed with pineal tissue together with the incubation medium; the spots were scraped and counted.

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Circadian rhythmicity of the activity of hydroxyindole-O-methyl transferase (HIOMT) in the formation of melatonin and 5-methoxytryptophol in the pineal, retina, and harderian gland of the golden hamster.

Pevet P, Balemans M, Legerstee W, Vivien-Roels B J Neural Transm. 1980; 49(4):229-45.

PMID: 7463036 DOI: 10.1007/BF01252128.


A survey of the location, isolation and identification of indoles, pteridines and some unknown active substances in sheep pineals. The possible significance of pteridines for the neuroendocrine control of neoplastic growth.

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Seasonal variations in HIOMT activity during the night in the pineal gland of 21 day old male Wistar rats.

Balemans M, Bary F, Legerstee W, van Benthem J J Neural Transm. 1980; 49(1-2):107-16.

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Methoxyindole synthesis in the retina of the frog (Rana esculenta) during a diurnal period.

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The influence of some pteridines on pineal 5-methoxyindole synthesis in male Wistar rats periodically exposed to either white or green light.

Balemans M, EBELS I, Hendriks H, van Berlo M, de Moree A J Neural Transm. 1983; 58(1-2):121-34.

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References
1.
Axelrod J, Weissbach H . Enzymatic O-methylation of N-acetylserotonin to melatonin. Science. 1960; 131(3409):1312. DOI: 10.1126/science.131.3409.1312. View

2.
Jackson R, Lovenberg W . Isolation and characterization of multiple forms of hydroxyindole-O-methyltransferase. J Biol Chem. 1971; 246(13):4280-5. View

3.
Axelrod J, Vesell E . Heterogeneity of N-and O-methyltransferases. Mol Pharmacol. 1970; 6(1):78-84. View

4.
Axelrod J, LAUBER J . Hydroxyindole-O-methyltransferase in several avian species. Biochem Pharmacol. 1968; 17(5):828-30. DOI: 10.1016/0006-2952(68)90022-1. View